LOXO-195
- Selitrectinib
- Optical Purity: 99% e.e.
- Soluble in DMSO
- MF: C20H21FN6O
- MW: 380.42
Description
LOXO-195 is an oral, second generation TRK inhibitor being made to address the acquired resistance to first generation TRK inhibitor (such as LOXO-101 (Axon 3407)). LOXO-195 potently and selectively inhibits, with minimal activity against other kinases, pan-TRKs (with potency on par with that of LOXO-101), and more importantly, abrogates resistance in TRK fusion–positive cancers that acquired kinase domain mutations due to the treatment of existing TRK inhibitors. Displays high oral bioavailability and favorable PK in animals.
More Information
| Parent CAS No. | 2097002-61-2 |
|---|---|
| Chemical Name | (3aR,10R)-5-Fluoro-1,2,3,3a,8,9,10,11-octahydro-10-methyl-12H-15,17-Ethenopyrazolo[3,4-d]pyrido[2,3-k]pyrrolo[2,1-m][1,3,7]triazacyclotridecin-12-one, |
| extra_info | Sold in collaboration with Chemietek |
| SMILES | C1C2[C@H]3CCCN3C3C=CN4N=CC(C(=O)N[C@H](C)CCC=2N=CC=1F)=C4N=3 |&1:2,17,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C20H21FN6O/c1-12-4-5-16-14(9-13(21)10-22-16)17-3-2-7-26(17)18-6-8-27-19(25-18)15(11-23-27)20(28)24-12/h6,8-12,17H,2-5,7H2,1H3,(H,24,28)/t12-,17-/m1/s1 |
| InChiKey | OEBIHOVSAMBXIB-SJKOYZFVSA-N |
| CID | 129103609 |
| Short Description | Trk inhibitor |
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