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AZ 23
- Optical Purity: Optically pure
- Soluble in DMSO
- MF: C17H19ClFN7O
- MW: 391.83
Description
AZ 23 is a potent and selective Trk kinase inhibitor with reported IC50 values of 2 nM for TrkA and 8 nM for TrkB.
Trk receptors mediate neurotrophin-dependent neuronal survival, differentiation and pain sensitization and can also act as oncogenic drivers when rearranged. AZ 23 is useful for studying TrkA/TrkB signaling, pain pathways and NTRK-dependent cancer biology.
Key Features
- Potent inhibitor of TrkA and TrkB kinases
- Reported IC50: 2 nM for TrkA and 8 nM for TrkB
- Blocks neurotrophin receptor signaling
- Useful for pain and oncogenic NTRK pathway research
Applications
- Trk kinase assays
- Neurotrophin signaling studies
- Pain sensitization model research
- NTRK-driven cancer model assays
More Information
| Parent CAS No. | 915720-21-7 |
|---|---|
| Chemical Name | (S)-5-chloro-N2-(1-(5-fluoropyridin-2-yl)ethyl)-N4-(5-isopropoxy-1H-pyrazol-3-yl)pyrimidine-2,4-diamine |
| SMILES | N(C1=NNC(OC(C)C)=C1)C1C(=CN=C(N[C@H](C2N=CC(F)=CC=2)C)N=1)Cl |&1:16,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C17H19ClFN7O/c1-9(2)27-15-6-14(25-26-15)23-16-12(18)8-21-17(24-16)22-10(3)13-5-4-11(19)7-20-13/h4-10H,1-3H3,(H3,21,22,23,24,25,26)/t10-/m0/s1 |
| InChiKey | LBVKEEFIPBQIMD-JTQLQIEISA-N |
| CID | 16097523 |
| Short Description | TrkA inhibitor |
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