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7,8-Dihydroxyflavone
- 7,8-DHF
Axon 2089
CAS:
38183-03-8
Purity:
99%
- Soluble in DMSO and EtOH
- MF: C15H10O4
- MW: 254.24
Description
Potent and selective tyrosine kinase receptor B (TrkB) agonist.
7,8-Dihydroxyflavone imitates Brain-derived neurotrophic factor (BDNF) and acts as a robust TrkB agonist, providing a powerful therapeutic tool for the treatment of various neurological diseases
More Information
| Parent CAS No. | 38183-03-8 |
|---|---|
| Chemical Name | 7,8-dihydroxy-2-phenyl-4H-chromen-4-one |
| SMILES | C1(C2=CC=CC=C2)OC2=C(O)C(O)=CC=C2C(=O)C=1 |
| MFCD | MFCD00006836 |
| InChi | InChI=1S/C15H10O4/c16-11-7-6-10-12(17)8-13(19-15(10)14(11)18)9-4-2-1-3-5-9/h1-8,16,18H |
| InChiKey | COCYGNDCWFKTMF-UHFFFAOYSA-N |
| CID | 1880 |
| Short Description | TrkB agonist |
References
- SW Jang et al. A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone. Proc. Natl. Acad. Sci. USA 2010, 107, 2687-2692.
- R Andero et al. Effect of 7, 8-dihydroxyflavone, a small-molecule TrkB agonist, on emotional learning. Am. J. Psychiatry 2011, 168(2), 163-172.
- L Devi & M Ohno. 7, 8-dihydroxyflavone, a small-molecule TrkB agonist, reverses memory deficits and BACE1 elevation in a mouse model of Alzheimer's disease. Neuropsychopharmacol. 2011, 37(2), 434-444.
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