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TrkB agonist prodrug R13
- Soluble in DMSO
- MF: C19H16N2O6
- MW: 368.34
Description
R13 is a prodrug of the selective TrkB agonist 7,8-DHF (Axon 2089) and inhibits AEP and promotes bone formation. TrkB agonist prodrug R13 significantly improved 7,8-DHF oral bioavailability and increased its brain exposure.
More Information
| Parent CAS No. | 1609067-49-3 |
|---|---|
| Chemical Name | 4-Oxo-2-phenyl-4H-chromene-7,8-diyl bis(methylcarbamate) |
| SMILES | C1(OC(NC)=O)C(OC(NC)=O)=C2OC(C3C=CC=CC=3)=CC(=O)C2=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C19H16N2O6/c1-20-18(23)26-14-9-8-12-13(22)10-15(11-6-4-3-5-7-11)25-16(12)17(14)27-19(24)21-2/h3-10H,1-2H3,(H,20,23)(H,21,24) |
| InChiKey | NWWRHMSYZTWUBD-UHFFFAOYSA-N |
| CID | 90117609 |
| Short Description | TrkB agonist |
References
- C Chen et al. The prodrug of 7,8-dihydroxyflavone development and therapeutic efficacy for treating Alzheimer's disease. Proc Natl Acad Sci U S A. 2018 Jan 16;115(3):578-583.
- X Li et al. R13 preserves motor performance in SOD1G93A mice by improving mitochondrial function. Theranostics. 2021 May 24;11(15):7294-7307.
- J Xiong et al. A TrkB agonist prodrug prevents bone loss via inhibiting asparagine endopeptidase and increasing osteoprotegerin. Nat Commun. 2022 Aug 16;13(1):4820.
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