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1,5-Isoquinolinediol
- NSC 65585
Axon 2537
CAS:
5154-02-9
Purity:
100%
- Soluble in 0.1N NaOH(aq) and DMSO
- MF: C9H7NO2
- MW: 161.16
Description
PARP1-specific inhibitor (IC50 value 0.39 - 1.00 μM) and neuroprotective agent, that leads to an increase up to 8-fold in the absolute frequency of gene targeting in the correction of the mutation at the stable integrated HSV tk gene in mouse Ltk cells. Treatment of 1,5-Isoquinolinediol significantly blocked mitochondrial membrane potential loss and AIF (apoptosis inducing factor) and cytochrome c release from the mitochondria. 1,5-Isoquinolinediol did not suppress pristimerin-induced JNK activation.
More Information
| Parent CAS No. | 5154-02-9 |
|---|---|
| Chemical Name | 5-hydroxyisoquinolin-1(2H)-one |
| MFCD | MFCD00006900 |
| Short Description | PARP inhibitor |
References
- A. Semionov et al. 1,5-isoquinolinediol increases the frequency of gene targeting by homologous recombination in mouse fibroblasts. Biochem Cell Biol. 2003 Feb;81(1):17-24.
- J.Y. Byun et al. Reactive oxygen species-dependent activation of Bax and poly(ADP-ribose) polymerase-1 is required for mitochondrial cell death induced by triterpenoid pristimerin in human cervical cancer cells. Mol Pharmacol. 2009 Oct;76(4):734-44.
- P. Decker et al. An improved nonisotopic test to screen a large series of new inhibitor molecules of poly(ADP-ribose) polymerase activity for therapeutic applications. Clin Cancer Res. 1999 May;5(5):1169-72.
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