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L67
Axon 2549
CAS:
325970-71-6
Purity:
99%
- Soluble in DMSO
- MF: C16H14Br2N4O4
- MW: 486.11
Description
L67 is a cytotoxic inhibitor of DNA ligase I and DNA ligase III. It binds the DNA-binding domain of human DNA ligase I, inhibiting DNA binding and ligation reactions.
DNA ligases I and III are essential for DNA replication, base excision repair and repair of strand breaks. L67 is useful for studying DNA repair vulnerability and sensitization of cancer cells to DNA-damaging agents.
Key Features
- DNA ligase I/III inhibitor
- Reported IC50 values: 10 µM for both DNA ligase I and DNA ligase III
- Interferes with DNA binding and ligation by hLigI
- Sensitizes cancer cells to DNA repair stress in reported studies
Applications
- DNA ligase enzyme pharmacology
- DNA repair pathway studies
- Cancer cell chemosensitization assays
- Replication and strand-break repair research
More Information
| Parent CAS No. | 325970-71-6 |
|---|---|
| Chemical Name | 2-(3,5-dibromo-4-methylphenylamino)-N'-(2-hydroxy-5-nitrobenzylidene)acetohydrazide |
| SMILES | C1(C)C(Br)=CC(NCC(=O)N/N=C/C2C(O)=CC=C([N+]([O-])=O)C=2)=CC=1Br |
| MFCD | N.A. |
| InChi | InChI=1S/C16H14Br2N4O4/c1-9-13(17)5-11(6-14(9)18)19-8-16(24)21-20-7-10-4-12(22(25)26)2-3-15(10)23/h2-7,19,23H,8H2,1H3,(H,21,24)/b20-7+ |
| InChiKey | KFEPVFJQVOMODD-IFRROFPPSA-N |
| CID | 135419707 |
| Short Description | DNA ligase inhibitor |
References
- X Chen et al. Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair.Cancer Res. 2008 May 1;68(9):3169-77.
- LA Tobin et al. Targeting abnormal DNA repair in therapy-resistant breast cancers. Mol Cancer Res. 2012 Jan;10(1):96-107.
- DK Singh et al. Human DNA ligases: a comprehensive new look for cancer therapy. Med Res Rev. 2014 May;34(3):567-95.
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