3PO

Based on 18 reference(s) in Google Scholar 9 10 18

Axon 2175

CAS [18550-98-6]

MF C13H10N2O
MW 210.23

  • Purity: 99%
  • Soluble in DMSO

3PO

Description

Inhibitor of HIF-1-induced PFKFB3, an enzyme with a key role in glycolysis. Potential application as suppressor of tumor glucose metabolism and growth of non-small cell lung cancer cells. The PFKFB3 family member has the highest kinase:bisphosphatase ratio (740:1) of the four known PFKFB family members. 3PO markedly attenuated the stimulation of F2,6BP synthesis, 2-[1-14C]-deoxy-D-glucose uptake, lactate secretion, TNF-α secretion and T cell aggregation and proliferation.
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Size Unit Price Stock
10 mg €65.00 In Stock
50 mg €165.00 In Stock
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Size Unit Price Stock
2 x 10 mg €90.00 In Stock
2 x 50 mg €230.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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