Akt Inhibitor VIII - Akti-1/2

Based on 16 publications in PubMed 9 10 16

Axon 2540

CAS [612847-09-3]

MF C34H29N7O
MW 551.64

  • Purity: 98%
  • Soluble in 0.1N HCl(aq) and DMSO

Akt Inhibitor VIII

Description

Non-ATP competitive inhibitor of Akt isoforms 1 and 2 (IC50 values 58 nM and 210 nM for Akt1 and Akt2, respectively). Moreover, the Akt inhibitor efficiently inhibits Ca2+/CaM-dependent protein kinase (CaMKIα) activity (IC50 value 3.99 μM) and prevents TCDD induced nuclear translocation of aryl hydrocarbon receptor (AhR) in MCF-7 cells. Akti-1/2 inhibitory effects towards CaMKIα and TCDD-induced EROD activity in function of Akti-1/2 concentrations were quite similar (IC50 ± SD, 3.99 ± 0.82 μM and 5.86 ± 1.85 μM, respectively).

KEYWORDS: Akt Inhibitor VIII | supplier | Akt inhibitor | Akti-1/2 | compound8 | inhibitorVIII | CAS [612847-09-3] | Phosphatidylinositol | Akt | PI3K | PKB | calcium | Ca2+/CaM-dependent protein kinase | CaMKIα | aryl hydrocarbon receptor | AhR | TCDD

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5 mg €125.00 In Stock
25 mg €425.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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