AIM 100

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 2031

CAS [873305-35-2]

MF C23H21N3O2
MW 371.43

Purity: 99%
Optical purity: 98.1% e.e.
Soluble in DMSO

AIM 100

Description

Specific inhibitor of Ack1 tyrosine kinase (also known as TNK2); AIM-100 inhibits Ack1 activity and also suppresses androgen receptor (AR) Tyr(267) phosphorylation and its recruitment to the ATM enhancer (Ack1/AR/ATM signaling)

K Mahajan et al. Effect of Ack1 tyrosine kinase inhibitor on ligand-independent androgen receptor activity. Prostate. 2010, 70(12), 1274-1285.

K Mahajan et al. Ack1 mediated androgen receptor phosphorylation modulates radiation resistance in castration resistant prostate cancer. J. Biol. Chem. 2012, 287(26), 22112-22122.

K Mahajan, NP Mahajan. Shepherding AKT and androgen receptor by Ack1 tyrosine kinase. J. Cell. Physiol. 2010, 224, 327–333.

Specific inhibitor of Ack1 tyrosine kinase (also known as TNK2)

Chemical name

(S)-5,6-diphenyl-N-((tetrahydrofuran-2-yl)methyl)furo[2,3-d]pyrimidin-4-amine

Parent CAS No.

[873305-35-2]

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Size	Unit Price	Stock
5 mg	€95.00	In Stock
10 mg	€140.00	In Stock
50 mg	€540.00	In Stock

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Size	Unit Price	Stock
2 x 10 mg	€220.00	In Stock

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2294	KRCA 0008	Potent and selective dual ALK/ACK1 inhibitor with good drug-like properties		€95.00
2762	XMD 8-87	Potent and selective inhibitor of Ack1 tyrosine kinase (also known as TNK2)		€95.00

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AIM 100

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AIM 100

Description

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