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Alpelisib
- NVP-BYL719 - BYL-719
- Optical Purity: Optically pure
- Soluble in DMSO
- MF: C19H22F3N5O2S
- MW: 441.47
Description
Alpelisib is a potent and selective PI3K α-isoform inhibitor with an IC50 value of 5 nM. Moreover, Alpelisib has shown good efficacy in inhibiting the growth of PI3K α-isoform driven tumors in animal xenograft models as well as good tolerability.
More Information
| Parent CAS No. | 1217486-61-7 |
|---|---|
| Chemical Name | (S)-N1-(4-Methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-yl)pyrrolidine-1,2-dicarboxamide |
| SMILES | C1(C2C=C(C(C(F)(F)F)(C)C)N=CC=2)=C(C)N=C(NC(=O)N2CCC[C@H]2C(=O)N)S1 |&1:25,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C19H22F3N5O2S/c1-10-14(11-6-7-24-13(9-11)18(2,3)19(20,21)22)30-16(25-10)26-17(29)27-8-4-5-12(27)15(23)28/h6-7,9,12H,4-5,8H2,1-3H3,(H2,23,28)(H,25,26,29)/t12-/m0/s1 |
| InChiKey | STUWGJZDJHPWGZ-LBPRGKRZSA-N |
| CID | 56649450 |
| Short Description | PI3K inhibitor |
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