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CAL 101
- Idelalisib
- Optical Purity: Optically pure
- Soluble in DMSO
- MF: C22H18FN7O
- MW: 415.42
Description
More Information
| Parent CAS No. | 870281-82-6 |
|---|---|
| Chemical Name | (S)-2-(1-(9H-purin-6-ylamino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one |
| SMILES | N1C2=C(C(F)=CC=C2)C(=O)N(C2=CC=CC=C2)C=1[C@@H](NC1=C2C(=NC=N1)NC=N2)CC |&1:18,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C22H18FN7O/c1-2-15(28-20-18-19(25-11-24-18)26-12-27-20)21-29-16-10-6-9-14(23)17(16)22(31)30(21)13-7-4-3-5-8-13/h3-12,15H,2H2,1H3,(H2,24,25,26,27,28)/t15-/m0/s1 |
| InChiKey | IFSDAJWBUCMOAH-HNNXBMFYSA-N |
| CID | 11625818 |
| Short Description | PI3K p110δ inhibitor |
References
- S.E.M. Herman et al. Phosphatidylinositol 3-kinase-δ inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals. Blood 2010, 116, 2078-2088.
- J. Hoellenriegel et al. The phosphoinositide 3'-kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia. Blood 2011, 118, 3603-3612.
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