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IC 87114
- Soluble in DMSO
- MF: C22H19N7O
- MW: 397.43
Description
IC 87114 is a potent and highly selective PI3K p110δ inhibitor with reported IC50 values of >100, 75, 29 and 0.5 µM for PI3Kα, PI3Kβ, PI3Kγ and PI3Kδ respectively. It inhibits PIP3 biosynthesis and neutrophil migration in immune-cell systems.
PI3Kδ is enriched in leukocytes and regulates immune-cell activation, chemotaxis and inflammatory responses. IC 87114 is pharmacologically relevant for immune PI3K signaling and inflammatory disease models.
Key Features
- Selective PI3Kδ/p110δ inhibitor
- High selectivity over PI3Kα, β and γ isoforms
- Inhibits PIP3 formation in neutrophils
- Modulates inflammatory cell migration
Applications
- PI3Kδ signaling studies
- Neutrophil migration assays
- Immune cell activation research
- Inflammation and autoimmune model profiling
More Information
| Parent CAS No. | 371242-69-2 |
|---|---|
| Chemical Name | 2-((6-amino-9H-purin-9-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one |
| SMILES | N1C2=C(C(C)=CC=C2)C(=O)N(C2=CC=CC=C2C)C=1CN1C2C(N=C1)=C(N)N=CN=2 |
| MFCD | MFCD09970845 |
| InChi | InChI=1S/C22H19N7O/c1-13-6-3-4-9-16(13)29-17(27-15-8-5-7-14(2)18(15)22(29)30)10-28-12-26-19-20(23)24-11-25-21(19)28/h3-9,11-12H,10H2,1-2H3,(H2,23,24,25) |
| InChiKey | GNWHRHGTIBRNSM-UHFFFAOYSA-N |
| CID | 9908783 |
| Short Description | PI3K p110δ inhibitor |
References
- C. Sadhu et al. Essential role of phosphoinositide 3-kinase delta in neutrophil directional movement. J. Immunol. 2003, 170, 2647-2654.
- D.P. Sutherlin et al. Potent and selective inhibitors of PI3Kδ: obtaining isoform selectivity from the affinity pocket and tryptophan shelf. Bioorg. Med. Chem. Lett. 2012, 22, 4296-302.
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