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NVP-BGT226
- BGT 226
- Parent CAS: 915020-55-2
- Soluble in DMSO
- MF: C28H25F3N6O2.C4H4O4
- MW: 650.6
Description
More Information
| Parent CAS No. | 915020-55-2 |
|---|---|
| Chemical Name | 8-(6-methoxypyridin-3-yl)-3-methyl-1-(4-(piperazin-1-yl)-3-(trifluoromethyl)phenyl)-1H-imidazo[4,5-c]quinolin-2(3H)-one maleate |
| SMILES | C1(C=C(C(F)(F)F)C(N2CCNCC2)=CC=1)N1C2C3=CC(C4C=NC(OC)=CC=4)=CC=C3N=CC=2N(C)C1=O.C(/C(O)=O)=C/C(O)=O |
| MFCD | MFCD22124895 |
| InChi | InChI=1S/C28H25F3N6O2.C4H4O4/c1-35-24-16-33-22-6-3-17(18-4-8-25(39-2)34-15-18)13-20(22)26(24)37(27(35)38)19-5-7-23(21(14-19)28(29,30)31)36-11-9-32-10-12-36;5-3(6)1-2-4(7)8/h3-8,13-16,32H,9-12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1- |
| InChiKey | YUXMAKUNSXIEKN-BTJKTKAUSA-N |
| CID | 57336745 |
| Short Description | PI3K/mTOR inhibitor |
References
- KY Chang et al. Novel phosphoinositide 3-kinase/mTOR dual inhibitor, NVP-BGT226, displays potent growth-inhibitory activity against human head and neck cancer cells in vitro and in vivo. Clin. Cancer Res. 2011, 17(22), 7116-26.
- W Glienke et al. The dual PI3K/mTOR inhibitor NVP-BGT226 induces cell cycle arrest and regulates Survivin gene expression in human pancreatic cancer cell lines. Tumour Biol. 2012, 33(3), 757-765.
- P Baumann et al. Simultaneous targeting of PI3K and mTOR with NVP-BGT226 is highly effective in multiple myeloma. Anticancer Drugs. 2012, 23(1), 131-138.
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