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5-NIdR
Axon 3476
CAS:
191421-10-0
- Optical Purity: Optically pure
- Soluble in water, DMSO and EtOH
- MF: C13H14N2O5
- MW: 278.26
Description
5-NIdR, a non-natural nucleoside, is as a potent inhibitor of translesion DNA synthesis (TLS) activity. Conversion of this compound to the corresponding nucleoside triphosphate, 5-nitroindolyl-2'-deoxyriboside triphosphate, in vivo creates a potent inhibitor of several human DNA polymerases that can replicate damaged DNA.
More Information
| Parent CAS No. | 191421-10-0 |
|---|---|
| Chemical Name | (2R,3S,5R)-2-(Hydroxymethyl)-5-(5-nitro-1H-indol-1-yl)tetrahydrofuran-3-ol |
| SMILES | C12C=CC([N+]([O-])=O)=CC=1C=CN2[C@@H]1O[C@H](CO)[C@@H](O)C1 |&1:12,14,17,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C13H14N2O5/c16-7-12-11(17)6-13(20-12)14-4-3-8-5-9(15(18)19)1-2-10(8)14/h1-5,11-13,16-17H,6-7H2/t11-,12+,13+/m0/s1 |
| InChiKey | ODPRBLIUAVWXNM-YNEHKIRRSA-N |
| CID | 15817525 |
| Short Description | TLS inhibitor |
References
- EA Motea et al. A non-natural nucleoside with combined therapeutic and diagnostic activities against leukemia. ACS Chem Biol. 2012 Jun 15;7(6):988-98.
- J Golden et al. Development and characterization of a non-natural nucleoside that displays anticancer activity against solid tumors. ACS Chem Biol. 2013 Nov 15;8(11):2452-65.
- JS Choi et al. Inhibition of Translesion DNA Synthesis as a Novel Therapeutic Strategy to Treat Brain Cancer. Cancer Res. 2018 Feb 15;78(4):1083-1096.
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