AICAR - Acadesine | NSC 105823 | AICA-riboside | Arasine

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 2389

CAS [2627-69-2]

MF C9H14N4O5
MW 258.23

  • Purity: 99%
  • Optical purity: Optically pure
  • Soluble in water and DMSO



Potent AMPK activator. AICAR activates AMPK due to increased phosphorylation, causes phosphorylation and inactivation of HMG-CoA reductase, and almost total cessation of fatty acid and sterol synthesis. AICAR causes ZMP (a cellular mimetic of AMP) to accumulate inside the cell but does not perturb the cellular contents of ATP, ADP or AMP, and induces differentiation of acute myeloid leukemia cells, and astroglial differentiation of neural stem cells via activating the JAK/STAT3 pathway independently of AMP-activated protein kinase. AICAR can also significantly up-regulate pluripotency-associated genes and down-regulate differentiation-associated transcription factors.

Caution: Axon Ligands™ are for research purposes only! Not for human consumption!

Size Unit Price Stock
10 mg €45.00 In Stock
50 mg €80.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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