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AG-270

Based on 3 reference(s) in Google Scholar 8 10 3

Axon 3515

CAS [2201056-66-6]

MF C30H27N5O2
MW 489.57

Purity: 98%
Soluble in DMSO

AG-270

Description

AG-270 is a first-in-class, highly potent, selective, orally bioavailable MAT2A inhibitor with an IC50 value of 0.014 μM.

KEYWORDS: AG-270 | Supplier | MAT2A inhibitor | AG 270 | AG270 | CAS [2201056-66-6] | Methionine | MAT | Inhibitor | Enzymes | Tumors with homozygous MTAP deletion | Methionine adenosyltransferase 2A | Methylthioadenosine phosphorylase | S-Adenosylmethionine synthetase | AdoMet | SAM | SAMe

Z Konteatis et al. Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor for the Treatment of Tumors with Homozygous MTAP Deletion. J Med Chem. 2021 Apr 22;64(8):4430-4449.

Cell Signaling & Oncology EC 2.5.1.6

First-in-class, highly potent, selective, orally bioavailable MAT2A inhibitor

Chemical name

3-Cyclohexenyl-6-(4-methoxyphenyl)-2-phenyl-5-(pyridin-2-ylamino)pyrazolo[1,5-a]pyrimidin-7(4H)-one

Parent CAS No.

[2201056-66-6]

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Size	Unit Price	Stock
5 mg	€180.00	In Stock
25 mg	€720.00	In Stock

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