(R)-HTS-3 hydrochloride

Based on 1 reference(s) in Google Scholar 8 10 1

Axon 3743

CAS [N.A.]

MF C17H18F2N2O.HCl
MW 340.80

  • Purity: 98%
  • Optical purity: 98% e.e.
  • Soluble in water, DMSO and EtOH

(R)-HTS-3 hydrochloride


(R)-HTS-3 hydrochloride is the first potent, selective, and cell-active inhibitor of LPCAT3 with an IC50 value of 0.09 μM. Human cells treated with (R)-HTS-3 undergo rapid remodeling of the acyl-chain composition of their phospholipids in a manner that mirrors the changes caused by genetic loss of LPCAT3. Acute blockade of LPCAT3 by (R)-HTS-3 confers partial protection against ferroptosis induced by GPX4 inhibition.

KEYWORDS: (R)-HTS-3 hydrochloride | Supplier | LPCAT3 inhibitor | (R)-HTS3 | (R)-HTS 3 | CAS [N.A.] | [2771208-83-2] | Lands cycle | LPCAT | Inhibitor | Enzymes | Ferroptosis | MBOAT5 | Lysophosphatidylcholine acyltransferase 3

Size Unit Price Stock
5 mg €150.00 In Stock
25 mg €580.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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