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ABC294640
- Opaganib
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C23H25ClN2O
- MW: 380.91
Description
ABC294640 is a selective and orally available Sphingosine kinase 2 inhibitor (SphK2 or SK2) in vitro, acting as a competitive inhibitor with respect to sphingosine with a Ki of 9.8 μM, and attenuates S1P formation in intact cells. In tissue culture, ABC294640 suppresses the proliferation of a broad panel of tumor cell lines, and inhibits tumor cell migration concomitant with loss of microfilaments. ABC294640 shows in vivo SK inhibitory activity in mice. Drug candidate for the treatment of cancer and other diseases.
More Information
| Parent CAS No. | 915385-81-8 |
|---|---|
| Chemical Name | 3-(4-Chlorophenyl)-N-(pyridin-4-ylmethyl)adamantane-1-carboxamide |
| SMILES | C1(Cl)C=CC(C23CC4CC(C(NCC5C=CN=CC=5)=O)(CC(C4)C2)C3)=CC=1 |
| MFCD | MFCD22666355 |
| InChi | InChI=1S/C23H25ClN2O/c24-20-3-1-19(2-4-20)22-10-17-9-18(11-22)13-23(12-17,15-22)21(27)26-14-16-5-7-25-8-6-16/h1-8,17-18H,9-15H2,(H,26,27) |
| InChiKey | CAOTVXGYTWCKQE-UHFFFAOYSA-N |
| CID | 15604015 |
| Short Description | SphK2 inhibitor |
References
- LW Maines et al. Suppression of ulcerative colitis in mice by orally available inhibitors of sphingosine kinase. Dig Dis Sci. 2008 Apr;53(4):997-1012.
- KJ French et al. Pharmacology and antitumor activity of ABC294640, a selective inhibitor of sphingosine kinase-2. J Pharmacol Exp Ther. 2010 Apr;333(1):129-39.
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