ABC294640 - Opaganib

Based on 63 reference(s) in Google Scholar 8 10 63

Axon 2880

CAS [915385-81-8]

MF C23H25ClN2O
MW 380.91

  • Purity: 98%
  • Soluble in 0.1N HCl(aq) and DMSO



ABC294640 is a selective and orally available Sphingosine kinase 2 inhibitor (SphK2 or SK2) in vitro, acting as a competitive inhibitor with respect to sphingosine with a Ki of 9.8 μM, and attenuates S1P formation in intact cells. In tissue culture, ABC294640 suppresses the proliferation of a broad panel of tumor cell lines, and inhibits tumor cell migration concomitant with loss of microfilaments. ABC294640 shows in vivo SK inhibitory activity in mice. Drug candidate for the treatment of cancer and other diseases.

KEYWORDS: ABC294640 | supplier | SphK2 inhibitor  | Opaganib | ABC 294640 | ABC-294640 | CAS [915385-81-8] | [1185157-59-8] | Sphingosine | SphK | Inhibitor | Enzymes | Ulcerative colitis | Crohn’s Disease | Inflammatory bowel disease

Size Unit Price Stock
10 mg €125.00 In Stock
50 mg €435.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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