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K 145 hydrochloride
- Parent CAS: 1309444-75-4
- Soluble in water and DMSO
- MF: C18H24N2O3S.HCl
- MW: 384.92
Description
K 145 hydrochloride is a selective, substrate-competitive sphingosine kinase 2 (SphK2) inhibitor with reported IC50 of 4.30 µM. It suppresses sphingosine-1-phosphate (S1P) levels and inhibits growth of U937 tumors after intraperitoneal and oral administration in reported studies.
SphK2 regulates sphingolipid signaling, S1P production, ERK/Akt activation and cancer cell survival. K 145 is relevant for studying SphK2-selective pharmacology without direct interference with ceramide kinase or ceramide synthase in the cited assays.
Key Features
- Selective SphK2 inhibitor
- Substrate-competitive inhibition mechanism
- Suppresses cellular S1P levels
- Antitumor activity reported in U937 xenograft models
Applications
- SphK2 enzyme assays
- Sphingolipid metabolism research
- S1P signaling studies
- Cancer cell survival and xenograft model profiling
More Information
| Parent CAS No. | 1309444-75-4 |
|---|---|
| Chemical Name | 3-(2-aminoethyl)-5-(3-(4-butoxyphenyl)propylidene)thiazolidine-2,4-dione hydrochloride |
| SMILES | S1/C(=CCCC2=CC=C(OCCCC)C=C2)/C(=O)N(CCN)C1=O.Cl |
| MFCD | N.A. |
| InChi | InChI=1S/C18H24N2O3S.ClH/c1-2-3-13-23-15-9-7-14(8-10-15)5-4-6-16-17(21)20(12-11-19)18(22)24-16;/h6-10H,2-5,11-13,19H2,1H3;1H/b16-6-; |
| InChiKey | HADFDMGQKBGVAV-NKBLJONXSA-N |
| CID | 76849910 |
| Short Description | SphK2 inhibitor |
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