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JTE 013
- Soluble in DMSO
- MF: C17H19Cl2N7O
- MW: 408.29
Description
JTE 013 is a potent and selective sphingosine-1-phosphate receptor 2 (S1P2/S1PR2) antagonist with a reported IC50 value of 17.6 nM.
S1P2 is a lipid-activated GPCR that regulates vascular tone, endothelial function, immune-cell movement and Rho-dependent cellular responses. JTE 013 is used to define S1P2-specific signaling within the broader S1P receptor family.
Key Features
- Selective S1P2 receptor antagonist
- Reported IC50: 17.6 nM
- Blocks sphingosine-1-phosphate receptor signaling
- Useful for vascular and immune-cell migration research
Applications
- S1P2/S1PR2 receptor pharmacology
- Lipid GPCR signaling studies
- Vascular biology and endothelial response assays
- Cell migration and Rho pathway research
More Information
| Parent CAS No. | 383150-41-2 |
|---|---|
| Chemical Name | N-(2,6-dichloropyridin-4-yl)-2-(4-isopropyl-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridin-6-yl)hydrazinecarboxamide |
| SMILES | C1(N=C2N(C)N=C(C)C2=C(C(C)C)C=1)NNC(=O)NC1C=C(Cl)N=C(Cl)C=1 |
| MFCD | MFCD08703118 |
| InChi | InChI=1S/C17H19Cl2N7O/c1-8(2)11-7-14(22-16-15(11)9(3)25-26(16)4)23-24-17(27)20-10-5-12(18)21-13(19)6-10/h5-8H,1-4H3,(H,22,23)(H2,20,21,24,27) |
| InChiKey | RNSLRQNDXRSASX-UHFFFAOYSA-N |
| CID | 10223146 |
| Short Description | S1PR2 antagonist |
References
- E Yokoo et al. Sphingosine 1-Phosphate Inhibits Migration of RBL-2H3 Cells via S1P2: Cross-Talk between Platelets and Mast Cells. J. Biochem. 2004, 135(6), 673-681.
- T McQuiston et al. Role of sphingosine-1-phosphate (S1P) and S1P receptor 2 in the phagocytosis of Cryptococcus neoformans by alveolar macrophages. Microbiology 2011, 157(5), 1416-1427.
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