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K6PC-5
- Soluble in DMSO
- MF: C19H37NO4
- MW: 343.5
Description
K6PC-5 is an activator of sphingosine kinase 1 (SphK1/SK1) that increases sphingosine-1-phosphate production. It activates S1P-linked survival signaling and protects osteoblasts from dexamethasone-induced apoptosis in reported studies.
SphK1 converts sphingosine to S1P, a bioactive lipid mediator involved in survival, migration, vascular function and immune signaling. K6PC-5 is useful for studying SphK1/S1P pathway activation in bone, inflammation and cell-survival models.
Key Features
- SphK1 activator
- Increases sphingosine-1-phosphate production
- Induces Akt phosphorylation in cultured osteoblasts
- Protects osteoblasts from dexamethasone-induced apoptosis in reported models
Applications
- SphK1/S1P signaling research
- Osteoblast survival and bone biology studies
- Lipid mediator pathway assays
- Akt-dependent cell-survival research
More Information
| Parent CAS No. | 756875-51-1 |
|---|---|
| Chemical Name | N-(1,3-dihydroxypropan-2-yl)-2-hexyl-3-oxodecanamide |
| SMILES | C(CCCCC)C(C(=O)CCCCCCC)C(=O)NC(CO)CO |
| MFCD | N.A. |
| InChi | InChI=1S/C19H37NO4/c1-3-5-7-9-11-13-18(23)17(12-10-8-6-4-2)19(24)20-16(14-21)15-22/h16-17,21-22H,3-15H2,1-2H3,(H,20,24) |
| InChiKey | CGYVFCHCRBGGJG-UHFFFAOYSA-N |
| CID | 11660192 |
| Short Description | SphK1 activator |
References
- F Ji et al. K6PC-5, a novel sphingosine kinase 1 (SphK1) activator, alleviates dexamethasone-induced damages to osteoblasts through activating SphK1-Akt signaling. Biochem Biophys Res Commun. 2015 Mar 13;458(3):568-75.
- JH Hong et al. K6PC-5, a direct activator of sphingosine kinase 1, promotes epidermal differentiation through intracellular Ca2+ signaling. J Invest Dermatol. 2008 Sep;128(9):2166-78.
- YB Kwon et al. Novel synthetic ceramide derivatives increase intracellular calcium levels and promote epidermal keratinocyte differentiation. J Lipid Res. 2007 Sep;48(9):1936-43.
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