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AM 095 (parent compound)
- Optical Purity: Optically pure
- Soluble in 0.1N NaOH(aq) and DMSO
- MF: C27H24N2O5
- MW: 456.49
Description
A novel potent and selective LPA1 antagonist (IC50 values 0.025 μM and 0.023 μM for AM095 antagonism of LPA-induced calcium flux of human or mouse LPA1-transfected CHO cells,respectively). AM 095 attenuates bleomycin-induced dermal fibrosis.
More Information
| Parent CAS No. | 1228690-36-5 |
|---|---|
| Chemical Name | (R)-2-(4'-(3-methyl-4-((1-phenylethoxy)carbonylamino)isoxazol-5-yl)biphenyl-4-yl)acetic acid |
| SMILES | C1(C2=CC=C(C3ON=C(C)C=3NC(O[C@@H](C3=CC=CC=C3)C)=O)C=C2)=CC=C(CC(O)=O)C=C1 |&1:14,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C27H24N2O5/c1-17-25(28-27(32)33-18(2)20-6-4-3-5-7-20)26(34-29-17)23-14-12-22(13-15-23)21-10-8-19(9-11-21)16-24(30)31/h3-15,18H,16H2,1-2H3,(H,28,32)(H,30,31)/t18-/m1/s1 |
| InChiKey | LNDDRUPAICPXIN-GOSISDBHSA-N |
| CID | 46213949 |
| Short Description | LPA1 antagonist |
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