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Amiselimod hydrochloride
- MT-1303
- Parent CAS: 942399-20-4
- Soluble in DMSO
- MF: C19H31ClF3NO3
- MW: 413.9
Description
Amiselimod hydrochloride is a prodrug sphingosine 1-phosphate (S1P) receptor modulator. Amiselimod is converted to its active metabolite, (S)-amiselimod phosphate (amiselimod-P), by sphingosine kinases. Amiselimod-P showed potent selectivity for S1P1 and high selectivity for S1P5 receptors, with minimal agonist activity for S1P4 and no distinct agonist activity for S1P2 or S1P3 receptors and approximately five-fold weaker GIRK activation than fingolimod-P.
More Information
| Parent CAS No. | 942399-20-4 |
|---|---|
| Chemical Name | 2-Amino-2-(4-(heptyloxy)-3-(trifluoromethyl)phenethyl)propane-1,3-diol hydrochloride |
| SMILES | C1C=C(OCCCCCCC)C(C(F)(F)F)=CC=1CCC(N)(CO)CO.Cl |
| MFCD | N.A. |
| InChi | InChI=1S/C19H30F3NO3.ClH/c1-2-3-4-5-6-11-26-17-8-7-15(12-16(17)19(20,21)22)9-10-18(23,13-24)14-25;/h7-8,12,24-25H,2-6,9-11,13-14,23H2,1H3;1H |
| InChiKey | GEDVJGOVRLHFQG-UHFFFAOYSA-N |
| CID | 67418070 |
| Short Description | S1PR modulator |
References
- AM Subei et al. Sphingosine 1-phosphate receptor modulators in multiple sclerosis. CNS Drugs. 2015 Jul;29(7):565-75.
- K Sugahara et al. Amiselimod, a novel sphingosine 1-phosphate receptor-1 modulator, has potent therapeutic efficacy for autoimmune diseases, with low bradycardia risk. Br J Pharmacol. 2017 Jan;174(1):15-27.
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