Nuclear Receptors

The nuclear receptor superfamily describes a related but diverse array of transcription factors (nuclear hormones). Upon activation by glucocorticoids, mineralocorticoids, sex steroids (estrogen, progesterone, and androgen), thyroid hormones, or vitamin D3, the nuclear receptors can bind a highly specific DNA sequence[1]. As a result, they regulate the expression of adjacent genes, thereby controlling the development, homeostasis, and metabolism of the organism. In the human genome, 48 different nuclear receptors are encoded, which can be classified into 6 evolutionary groups, based on their sequence alignment and phylogenetic tree[2]. All NR proteins exhibit a characteristic modular structure that consists of five to six domains of homology on the basis of regions (A-F) of conserved sequence and function. The DNA-binding domain (DBD, region C), absent in DAX-1 and SHP, and the ligand-binding domain (LBD; region E) are the most highly conserved domains. These two regions are the most important and can function independently.


[1] Nuclear Receptor Minireview Series. J.M. Olefsky. J. Biol. Chem. 2001, 276, 36863-36864.
[2] Overview of Nomenclature of Nuclear Receptors. P. Germain et al. Pharmacol Rev 2006, 58, 685-704.

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Axon ID Name Description From price
2679 AR7 RARα antagonist that stimulates chaperone-mediated autophagy €90.00
1979 ARN 509 Antagonist of androgen receptor (AR) €95.00
1675 Asoprisnil Progesterone receptor (PR) modulator €120.00
1748 Bazedoxifene hydrochloride Selective estrogen receptor modulator (SERM) €80.00
1700 Bexarotene Retinoid X Receptor antagonist €65.00
1940 BI 6015 Potent hepatocyte nuclear factor 4α (HNF4α) antagonist €120.00
1194 BMS 189961 RAR-γ agonist €145.00
1173 BMS 270394 RAR-γ agonist €165.00
1676 BXL 628 Vitamin D receptor (VDR) agonist €165.00
2575 C-DIM12 Nurr1 activator that stimulates apoptosis in bladder cancer cells €85.00
1950 CDDO A potent multifunctional anti-tumor agent. PPAR-γ agonist €120.00
1241 CH 55 RAR agonist €90.00
1426 Ciclesonide Glucocorticoid €65.00
2114 CP 775146 Potent and selective PPARα agonist €85.00
1427 Diflorasone Diacetate Corticosteroid €95.00

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