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KPT-330
- Selinexor
Axon 2336
CAS:
1393477-72-9
Purity:
99%
- Soluble in DMSO
- MF: C17H11F6N7O
- MW: 443.31
Description
KPT-330 (Selinexor) is a potent, selective and orally available exportin-1 (XPO1/CRM1) inhibitor and first-in-class selective inhibitor of nuclear export (SINE). It blocks CRM1-dependent nuclear export of tumor suppressor and regulatory proteins, altering nuclear-cytoplasmic protein trafficking.
XPO1-mediated export controls localization of many proteins involved in cell-cycle regulation, apoptosis and oncogenic transcription. KPT-330 is useful for studying nuclear export dependency and translational oncology mechanisms.
Key Features
- Selective XPO1/CRM1 inhibitor
- First-in-class SINE compound
- Blocks nuclear export of regulatory proteins
- Orally available pharmacological profile
Applications
- Nuclear export research
- XPO1/CRM1 pathway assays
- Oncology target-validation studies
- Tumor suppressor localization research
More Information
| Parent CAS No. | 1393477-72-9 |
|---|---|
| Chemical Name | (Z)-3-(3-(3,5-Bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-N'-(pyrazin-2-yl)acrylohydrazide |
| SMILES | C1(C(F)(F)F)C=C(C2=NN(/C=CC(NNC3N=CC=NC=3)=O)C=N2)C=C(C(F)(F)F)C=1 |
| MFCD | MFCD27987944 |
| InChi | InChI=1S/C17H11F6N7O/c18-16(19,20)11-5-10(6-12(7-11)17(21,22)23)15-26-9-30(29-15)4-1-14(31)28-27-13-8-24-2-3-25-13/h1-9H,(H,25,27)(H,28,31)/b4-1- |
| InChiKey | DEVSOMFAQLZNKR-RJRFIUFISA-N |
| CID | 71481097 |
| Short Description | XPO1/CRM1 inhibitor |
References
- J Gerecitano et al. SINE (selective inhibitor of nuclear export)--translational science in a new class of anti-cancer agents. J Hematol Oncol. 2014 Oct 4;7:67.
- GL Gravina et al. KPT-330, a potent and selective exportin-1 (XPO-1) inhibitor, shows antitumor effects modulating the expression of cyclin D1 and survivin [corrected] in prostate cancer models. BMC Cancer. 2015 Dec 1;15:941.
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