XPO

XPO1 is the best-characterized nuclear exporter of the karyopherin-β superfamily of nuclear transport proteins, which includes 15 different importin and exportin proteins. XPO1 is involved in transporting approximately 220 proteins and certain RNA species from the nucleus to the cytoplasm through the nuclear pore complex. In the nucleus, XPO1 forms a quaternary complex with one of a diverse array of cargo proteins, Ran-GTP, and Ran-BP3. In the cytoplasm, the complex is dissociated through the combined action of Ran-GAP and Ran-BP1. Selective inhibitors of nuclear export (SINE) have proven to be effective as inhibitors of the replication of various influenza A and B virus strains[1], and as anti-cancer agents[2], for example.


[1] O Perwitasari et al. Verdinexor, a novel selective inhibitor of nuclear export, reduces influenza a virus replication in vitro and in vivo. J Virol. 2014 Sep 1;88(17):10228-43.
[2] K Parikh et al. Selective inhibitors of nuclear export (SINE)--a novel class of anti-cancer agents. J Hematol Oncol. 2014 Oct 15;7:78.

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Axon ID Name Description From price
2597 KPT 335 XPO1 inhibitor; selective inhibitor of nuclear export (SINE) €105.00

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