Transporters
Four fundamentally different classes of membrane-bound transport proteins exist in organisms: ion channels; transporters; aquaporins; and ATP-powered pumps. Transport proteins serve the function of moving other materials within an organism. Basically, there are two different types of transport proteins: those that carry molecules to "distant" locations (within a cell or an organism), and those that serve as gateways, carrying molecules across otherwise impermeable membranes[1]. One example of a specific transporter that plays a key role in the metabolism of many organisms is the sodium dependent glucose co-transporter (SGLT), for example. A protein highly abundant in kidneys, that serves renal glucose reabsorption, and therefore is of high interest as a target for the treatment of diabetes[2] (for example SGLT2 inhibitor Remogliflozin (Axon 1634)).
[1] J.M. Berg, J.L. Tymoczko, L. Stryer. Biochemistry, 2002, 5th edition.New York. W. H. Freeman.
[2] Remogliflozin etabonate, in a Novel Category of Selective Low-Affinity / High-Capacity Sodium Glucose Cotransporter (SGLT2) Inhibitors, Exhibits Antidiabetic Efficacy in Rodent Models. Y. Fujimori, K. Katsuno,I. Nakashima, Y. Ishikawa-Takemura, H. Fujikura, M. Isaji. J. Pharmacol. Exp. Ther. 2008, 327, 268–276.
| Axon ID | Name | Description | From price | |
|---|---|---|---|---|
| 3777 | (R)-AS-1 | First-in-class highly selective and orally bioavailable PAM of EAAT2 | €145.00 | |
| 3564 | ABCA1 inducer compound G | ABCA1 inducer targeting OSBPL7 | €150.00 | |
| 1238 | ALX 5407 hydrochloride | GlyT-1 inhibitor | €140.00 | |
| 1333 | Amoxapine | Tricyclic antidepressant; Potent reuptake inhibitor of norepinephrine (NRI) | €50.00 | |
| 2941 | ARN 272 | Selective inhibitor of FAAH-like anandamide transporter (FLAT) | €90.00 | |
| 1297 | Atomoxetine hydrochloride | NRI inhibitor | €95.00 | |
| 2099 | Avridine | Lipoidal amine; interferon-inducing and adjuvant properties | €80.00 | |
| 1462 | Azaphen | Antidepressant | €105.00 | |
| 4070 | AZD3965 | Monocarboxylate transporter 1 (MCT1) inhibitor | Recently added | Inquire |
| 2660 | BAY-876 | Inhibitor of glucose transporter 1 (GLUT1) | €105.00 | |
| 2976 | BI 01383298 | Potent and selective Na+/citrate cotransporter inhibitor | €95.00 | |
| 3699 | BMS-466442 | Selective asc-1 inhibitor | €140.00 | |
| 1257 | BTS 54-505 | 5-HT uptake inhibitor | €85.00 | |
| 1451 | Bupropion hydrochloride | DRI and NRI; nicotinic acetylcholine receptor antagonist | €85.00 | |
| 3122 | Canagliflozin | Highly potent and selective SGLT2 inhibitor | €70.00 | |
| 3619 | Chlorphentermine hydrochloride | Serotonin transporter (SERT) substrate | €95.00 | |
| 1320 | Citalopram hydrobromide | SSRI; Antidepressant | €75.00 | |
| 1654 | CP 100356 hydrochloride | P-gp inhibitor | €90.00 | |
| 2216 | CP 346086 | Potent microsomal triglyceride transfer protein (MTP) inhibitor | €140.00 | |
| 3358 | CTPI-2 | Specific SLC25A1 inhibitor | €60.00 | |
| 1962 | Dalcetrapib | Inhibitor of cholesterylester transfer protein (CETP) | €135.00 | |
| 3121 | Dapagliflozin | Potent and selective hSGLT2 inhibitor | €60.00 | |
| 2284 | Deltarasin trihydrochloride | Inhibitor of the prenyl binding protein PDEδ and the KRAS–PDEδ interaction. | €120.00 | |
| 1722 | Deshydroxy Venlafaxine HCl | Metabolite of Venlafaxine; SNRI | €95.00 | |
| 3555 | Desvenlafaxine hydrochloride | Metabolite of Venlafaxine; SNRI | €70.00 | |
| 2987 | DFP00173 | Potent and selective AQP3 inhibitor | €140.00 | |
| 1726 | Dinorvenlafaxine | Metabolite of Venlafaxine; SNRI | €75.00 | |
| 3881 | ECSI#6 | First uncompetitive serotonin transporter (SERT) inhibitor | €140.00 | |
| 1896 | Elacridar hydrochloride | P-gp inhibitor (3rd generation ABCB1 modulator) | €80.00 | |
| 3367 | Empagliflozin | Potent and selective SGLT2 inhibitor | €80.00 | |