Four fundamentally different classes of membrane-bound transport proteins exist in organisms: ion channels; transporters; aquaporins; and ATP-powered pumps. Transport proteins serve the function of moving other materials within an organism. Basically, there are two different types of transport proteins: those that carry molecules to "distant" locations (within a cell or an organism), and those that serve as gateways, carrying molecules across otherwise impermeable membranes. One example of a specific transporter that plays a key role in the metabolism of many organisms is the sodium dependent glucose co-transporter (SGLT), for example. A protein highly abundant in kidneys, that serves renal glucose reabsorption, and therefore is of high interest as a target for the treatment of diabetes (for example SGLT2 inhibitor Remogliflozin (Axon 1634)).
 J.M. Berg, J.L. Tymoczko, L. Stryer. Biochemistry, 2002, 5th edition.New York. W. H. Freeman.
 Remogliflozin etabonate, in a Novel Category of Selective Low-Affinity / High-Capacity Sodium Glucose Cotransporter (SGLT2) Inhibitors, Exhibits Antidiabetic Efficacy in Rodent Models. Y. Fujimori, K. Katsuno,I. Nakashima, Y. Ishikawa-Takemura, H. Fujikura, M. Isaji. J. Pharmacol. Exp. Ther. 2008, 327, 268–276.
|Axon ID||Name||Description||From price|
|1238||ALX 5407 hydrochloride||GlyT-1 inhibitor||€135.00|
|1333||Amoxapine||Tricyclic antidepressant; Potent reuptake inhibitor of norepinephrine (NRI)||€50.00|
|1297||Atomoxetine hydrochloride||NRI inhibitor||€95.00|
|1257||BTS 54-505||5-HT uptake inhibitor||€85.00|
|1451||Bupropion hydrochloride||DRI and NRI; nicotinic acetylcholine receptor antagonist||€85.00|
|1320||Citalopram hydrobromide||SSRI; Antidepressant||€75.00|
|1654||CP 100356 hydrochloride||P-gp inhibitor||€125.00|
|2216||CP 346086||Potent microsomal triglyceride transfer protein (MTP) inhibitor||€125.00|
|1962||Dalcetrapib||Inhibitor of cholesterylester transfer protein (CETP)||€135.00|
|2284||Deltarasin trihydrochloride||Inhibitor of the prenyl binding protein PDEδ and the KRAS–PDEδ interaction.||€125.00|
|1722||Deshydroxy Venlafaxine HCl||Metabolite of Venlafaxine; SNRI||€95.00|
|2116||Desmethylvenlafaxine succinate, O-||Metabolite of Venlafaxine; SNRI||€95.00|
|1720||Desmethylvenlafaxine, R-(-)-O-||Metabolite of Venlafaxine; SNRI||€125.00|
|1721||Desmethylvenlafaxine, S-(+)-O-||Metabolite of Venlafaxine; SNRI||€125.00|