Transporters

Four fundamentally different classes of membrane-bound transport proteins exist in organisms: ion channels; transporters; aquaporins; and ATP-powered pumps. Transport proteins serve the function of moving other materials within an organism. Basically, there are two different types of transport proteins: those that carry molecules to "distant" locations (within a cell or an organism), and those that serve as gateways, carrying molecules across otherwise impermeable membranes[1]. One example of a specific transporter that plays a key role in the metabolism of many organisms is the sodium dependent glucose co-transporter (SGLT), for example. A protein highly abundant in kidneys, that serves renal glucose reabsorption, and therefore is of high interest as a target for the treatment of diabetes[2] (for example SGLT2 inhibitor Remogliflozin (Axon 1634)).


[1] J.M. Berg, J.L. Tymoczko, L. Stryer. Biochemistry, 2002, 5th edition.New York. W. H. Freeman.
[2] Remogliflozin etabonate, in a Novel Category of Selective Low-Affinity / High-Capacity Sodium Glucose Cotransporter (SGLT2) Inhibitors, Exhibits Antidiabetic Efficacy in Rodent Models. Y. Fujimori, K. Katsuno,I. Nakashima, Y. Ishikawa-Takemura, H. Fujikura, M. Isaji. J. Pharmacol. Exp. Ther. 2008, 327, 268–276.

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Axon ID Name Description From price
1549 SSR 504734 GlyT-1 inhibitor €105.00
1905 STF 31 Inhibitor of glucose transporter 1 (GLUT1) €125.00
1960 Tariquidar Inhibitor of P-glycoprotein (P-gp, ABCB1) €135.00
2640 TFB-TBOA Very potent blocker of human excitatory amino acid transporters (EAAT1-2) €145.00
2422 TGN 020 Aquaporin 4 (AQP4) inhibitor. Useful pharmacological tool. €80.00
2047 Torcetrapib Inhibitor of cholesterylester transfer protein (CETP) €85.00
1111 UCB-L 060 Least active enantiomer of Axon 1109 €120.00
2805 UK 5099 Inhibitor of mitochondrial pyruvate carrier (MPC) €105.00
2581 UR 1102 Selective inhibitor of the renal urate transporter URAT1 €105.00
1727 Venlafaxine hydrochloride SNRI €65.00
2938 Verinurad Highly potent and selective inhibitor of the renal urate transporter URAT1 €95.00
2670 VU6001221 Choline transporter inhibitor €125.00
1724 WY 45494 hydrochloride Metabolite of Venlafaxine; SNRI €75.00
1723 WY 45960 hydrochloride Metabolite of Venlafaxine; SNRI €95.00
1725 WY 46689 Metabolite of Venlafaxine; SNRI €75.00

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