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ALX 5407 hydrochloride
- NFPS
Axon 1238
- Parent CAS: 571147-18-7
- Optical Purity: 98% e.e.
- Soluble in DMSO
- MF: C24H24FNO3.HCl
- MW: 429.91
Description
ALX 5407 hydrochloride is a potent, selective and irreversible human glycine transporter 1 (GlyT1) inhibitor.
GlyT1 controls extracellular glycine availability and thereby modulates NMDA receptor co-agonist tone. ALX 5407 is used to study glycinergic neurotransmission, NMDA receptor modulation and CNS disease-related pathways such as schizophrenia research.
Key Features
- Potent irreversible GlyT1 inhibitor
- Increases extracellular glycine availability
- Modulates NMDA receptor co-agonist tone
- Useful for CNS glycine transporter pharmacology
Applications
- GlyT1 uptake assays
- NMDA receptor modulation studies
- Schizophrenia-related CNS pathway research
- Glycinergic neurotransmission models
More Information
| Parent CAS No. | 571147-18-7 |
|---|---|
| Chemical Name | (R)-2-((3-(Biphenyl-4-yloxy)-3-(4-fluorophenyl)propyl)(methyl)amino)acetic acid hydrochloride |
| SMILES | Cl.C1(C2C=CC(=CC=2)O[C@H](CCN(C)CC(=O)O)C2=CC=C(F)C=C2)C=CC=CC=1 |&1:9,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C24H24FNO3.ClH/c1-26(17-24(27)28)16-15-23(20-7-11-21(25)12-8-20)29-22-13-9-19(10-14-22)18-5-3-2-4-6-18;/h2-14,23H,15-17H2,1H3,(H,27,28);1H/t23-;/m1./s1 |
| InChiKey | RPDGSZCYSJWQEE-GNAFDRTKSA-N |
| CID | 16078946 |
| Short Description | GlyT-1 inhibitor |
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