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ORG 25935
- SCH 900435
Axon 1563
- Parent CAS: 754965-07-6
Purity:
99%
- Soluble in DMSO
- MF: C21H25NO3.HCl
- MW: 375.89
Description
ORG 25935 (SCH900435) is a potent and selective GlyT1 inhibitor that blocks glycine reuptake at glycinergic and glutamatergic synapses.
Increasing extracellular glycine can enhance NMDA receptor co-agonist availability, a mechanism relevant to glutamatergic dysfunction in neuropsychiatric research. ORG 25935 is useful for studying GlyT1 inhibition and NMDA receptor modulation in CNS models.
Key Features
- Selective glycine transporter 1 inhibitor
- Blocks glycine reuptake and increases glycine availability
- Relevant to NMDA receptor co-agonist signaling
- Tool compound for schizophrenia-related glutamatergic research
Applications
- GlyT1 transporter pharmacology
- NMDA receptor modulation studies
- Schizophrenia and cognitive symptom models
- CNS synaptic signaling assays
More Information
| Parent CAS No. | 754965-07-6 |
|---|---|
| Chemical Name | rel-[((1R,2S)-6-Methoxy-1-phenyl-1,2,3,4-tetrahydro-naphthalen-2-ylmethyl)-methyl-amino]-acetic acid hydrochloride |
| MFCD | MFCD19708017 |
| Short Description | GlyT-1 inhibitor |
ORG 25935 (SCH900435)
glycine transporter 1 inhibitor
ORG 25935
SCH900435
SCH 900435
ORG25935
GlyT-1
glycine transporter 1
Inhibitor
glutamatergic signaling
GlyT1 transporter pharmacology
NMDA receptor modulation studies
Schizophrenia and cognitive symptom models
CNS synaptic signaling assays
cognition
transporter pharmacology
receptor selectivity
signal transduction
receptor pharmacology
CNS
CAS 1147011-84-4
CAS 949588-40-3
Axon Medchem
Axon 1563
Supplier
Vendor
References
- HH Lidoe et al. The glycine reuptake inhibitor Org 25935 interacts with basal and ethanol-induced dopamine release in rat nucleus accumbens. Alcoholism: Clin. Exp. Res. 2009, 33(7), 1151-1157.
- K Morita et al. Spinal antiallodynia action of glycine transporter inhibitors in neuropathic pain models in mice. J. Pharmacol. Exp. Ther. 2008, 326(2), 633-645.
- A Molander et al. The glycine reuptake inhibitor Org 25935 decreases ethanol intake and preference in male Wistar rats. Alcohol and Alcoholism (Oxford, United Kingdom) (2007), 42(1), 11-18.
- K Hashimoto. Glycine Transporter Inhibitors as Therapeutic Agents for Schizophrenia. Recent Patents on CNS Drug Discovery, 2006, 1, 43-53.
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