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SSR 504734
Axon 1549
- Parent CAS: 742693-38-5
- Optical Purity: >98% e.e.
- Soluble in water and DMSO
- MF: C20H20ClF3N2O.HCl
- MW: 433.29
Description
SSR 504734 is a potent, selective and orally active GlyT1 inhibitor that blocks glycine uptake.
GlyT1 inhibition increases extracellular glycine availability at NMDA receptor co-agonist sites, making this mechanism relevant to glutamatergic neurotransmission and cognitive symptom research. SSR 504734 is useful for studying glycine transporter pharmacology and NMDA pathway modulation.
Key Features
- Selective inhibitor of glycine transporter 1 (GlyT1)
- Rapidly and reversibly blocks glycine uptake ex vivo
- Enhances glycine-dependent modulation of NMDA receptor signaling
- Useful tool for cognitive and psychiatric pharmacology research
Applications
- GlyT1 transporter assays
- NMDA receptor modulation studies
- Schizophrenia-related glutamatergic research
- CNS cognition pathway models
More Information
| Parent CAS No. | 742693-38-5 |
|---|---|
| Chemical Name | 2-chloro-3-(trifluoromethyl)-N-((S)-phenyl((S)-piperidin-2-yl)methyl)benzamide hydrochloride |
| SMILES | C1(C(F)(F)F)=C(Cl)C(C(=O)N[C@@H](C2=CC=CC=C2)[C@]2([H])CCCCN2)=CC=C1.Cl |&1:11,18,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C20H20ClF3N2O.ClH/c21-17-14(9-6-10-15(17)20(22,23)24)19(27)26-18(13-7-2-1-3-8-13)16-11-4-5-12-25-16;/h1-3,6-10,16,18,25H,4-5,11-12H2,(H,26,27);1H/t16-,18-;/m0./s1 |
| InChiKey | YGCZZYKACZXKHK-AKXYIILFSA-N |
| CID | 9954539 |
| Short Description | GlyT-1 inhibitor |
References
- G Depoortere et al. Neurochemical, electrophysiological and pharmacological profiles of the selective inhibitor of the glycine transporter-1 SSR504734, a potential new type of antipsychotic. Neuropsychopharmacology 2005, 30, 1963–1985.
- K Hashimoto. Glycine Transporter Inhibitors as Therapeutic Agents for Schizophrenia. Recent Pat. CNS Drug Discov. 2006, 1, 43-53.
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