Transporters

Four fundamentally different classes of membrane-bound transport proteins exist in organisms: ion channels; transporters; aquaporins; and ATP-powered pumps. Transport proteins serve the function of moving other materials within an organism. Basically, there are two different types of transport proteins: those that carry molecules to "distant" locations (within a cell or an organism), and those that serve as gateways, carrying molecules across otherwise impermeable membranes[1]. One example of a specific transporter that plays a key role in the metabolism of many organisms is the sodium dependent glucose co-transporter (SGLT), for example. A protein highly abundant in kidneys, that serves renal glucose reabsorption, and therefore is of high interest as a target for the treatment of diabetes[2] (for example SGLT2 inhibitor Remogliflozin (Axon 1634)).


[1] J.M. Berg, J.L. Tymoczko, L. Stryer. Biochemistry, 2002, 5th edition.New York. W. H. Freeman.
[2] Remogliflozin etabonate, in a Novel Category of Selective Low-Affinity / High-Capacity Sodium Glucose Cotransporter (SGLT2) Inhibitors, Exhibits Antidiabetic Efficacy in Rodent Models. Y. Fujimori, K. Katsuno,I. Nakashima, Y. Ishikawa-Takemura, H. Fujikura, M. Isaji. J. Pharmacol. Exp. Ther. 2008, 327, 268–276.

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Axon ID Name Description From price
3121 Dapagliflozin Potent and selective hSGLT2 inhibitor €60.00
2284 Deltarasin trihydrochloride Inhibitor of the prenyl binding protein PDEδ and the KRAS–PDEδ interaction. €115.00
1722 Deshydroxy Venlafaxine HCl Metabolite of Venlafaxine; SNRI €95.00
2987 DFP00173 Potent and selective AQP3 inhibitor €140.00
1726 Dinorvenlafaxine Metabolite of Venlafaxine; SNRI €75.00
1896 Elacridar hydrochloride P-gp inhibitor (3rd generation ABCB1 modulator) €80.00
3367 Empagliflozin Potent and selective SGLT2 inhibitor €80.00
3315 Escitalopram oxalate SSRI; Antidepressant €50.00
1109 Etiracetam Racemate of Axon 1110 and Axon 1111 €75.00
2286 Evacetrapib Potent, and selective inhibitor of CETP €125.00
2904 Exo1 Inhibitor of the exocytic pathway €50.00
2277 FLI 06 Notch signaling inhibitor that acts early in the secretory pathway €95.00
1302 Fluoxetine hydrochloride SSRI €75.00
1556 Fluvoxamine maleate SSRI €60.00
1203 GBR 12783 dihydrochloride Dopamine uptake inhibitor €85.00

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