MCT

Monocarboxylate transporters (MCTs) are members of the solute carrier (SLC) family (SLC16) of proteins. MCTs are present in a wide variety of tissues and are involved in the regulation of fundamental cellular processes, such as glycolysis, fatty acid homeostasis, as well as other key metabolic pathways. Of the 14 isoforms identified, proton-dependent MCTs 1–4 have been extensively studied due to their importance in transporting L-lactate, pyruvate, and short-chain fatty acids in a wide variety of tissues. Most importantly, many of these MCT isoforms are upregulated in tumor tissues, making them attractive targets and biomarkers for a wide variety of cancers.[1]


[1] R.S. Jones et al. Monocarboxylate Transporters: Therapeutic Targets and Prognostic Factors in Disease. Clin Pharmacol Ther. 2016 Nov;100(5):454-463.

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Axon ID Name Description From price
3838 AZD0095 Potent, selective and orally active MCT4 inhibitor €160.00
4070 AZD3965 Monocarboxylate transporter 1 (MCT1) inhibitor Inquire
2805 UK 5099 Inhibitor of mitochondrial pyruvate carrier (MPC) €105.00

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