Synaptic vesicle protein 2 (SV2) is a membrane glycoprotein found only in the secretory vesicles of neural and endocrine cells. Three isoforms of this 90-kDa protein exist: SV2A, SV2B, and SV2C, of which, SV2A is the most widely distributed. The molecular mechanism by which these proteins regulate secretion is not clear[1]. Based on predicted structure and amino acid sequences, the SV2 proteins belong to the major facilitator superfamily of transporter proteins, with a high degree of homology with glucose transporters (GLUTs) and plasma membrane transporters for neurotransmitters[2]. Other studies demonstrated that SV2A deletion results in reduced action potential-dependent release of the inhibitory neurotransmitter GABA in the hippocampus. These observations have given rise to the hypothesis that SV2A dysfunction is associated with calcium accumulation during repeated action potential generation. The effect, in turn, leads to increased neurotransmitter release and a destabilization of neuronal circuits, facilitated by excitatory transmission and a concurrent attenuation of inhibition. It would explain why SV2A knockout mice have spontaneous seizures from birth and typically die within 3 weeks[3]. Similar studies also revealed that SV2A is the brain binding site of levetiracetam (Axon 1110), an antiepileptic drug with a unique activity profile in animal models of seizure and epilepsy[4].

[1] A. Pitkänen. SV2A: More Than Just a New Target for AEDs. Epilepsy Curr. 2005, 5, 14-16.
[2] M.B. Feany et al. The synaptic vesicle protein SV2 is a novel type of transmembrane transporter. Cell. 1992, 70, 861-867.
[3] G.J. Sills. SV2A in Epilepsy: The Plot Thickens. Epilepsy Curr. 2010, 10, 47-49.
[4] B.A. Lynch et al. The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam. Proc. Natl. Acad. Sci. USA. 2004, 101, 9861-9866.

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Axon ID Name Description From price
2941 ARN 272 Selective inhibitor of FAAH-like anandamide transporter (FLAT) €90.00
3838 AZD0095 Potent, selective and orally active MCT4 inhibitor  Recently added €160.00
4070 AZD3965 Monocarboxylate transporter 1 (MCT1) inhibitor Inquire
2284 Deltarasin trihydrochloride Inhibitor of the prenyl binding protein PDEδ and the KRAS–PDEδ interaction. €120.00
1109 Etiracetam Racemate of Axon 1110 and Axon 1111 €75.00
2904 Exo1 Inhibitor of the exocytic pathway €50.00
2277 FLI 06 Notch signaling inhibitor that acts early in the secretory pathway €95.00
1110 Levetiracetam Binds synaptic vesicle protein 2A (SV2A) €85.00
3622 NAV-2729 Dual Arf1/Arf6 inhibitor; FATP2 inhibitor €80.00
2303 R 55 Retromer stabilizing pharmacological chaperone. Potential Alzheimer's therapeutic €95.00
3702 SLF1081851 hydrochloride Spns2 inhibitor €120.00
3533 Tafamidis Selective TTR stabilizer €90.00
1111 UCB-L 060 Least active enantiomer of Axon 1109 €120.00
2805 UK 5099 Inhibitor of mitochondrial pyruvate carrier (MPC) €105.00

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