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R55
- NSC 55712 - TPT 260 dihydrochloride
- Parent CAS: 769856-81-7
- Soluble in water and DMSO
- MF: C8H12N4S3.2HCl
- MW: 333.32
Description
R55 (TPT-260) is a retromer-stabilizing pharmacological chaperone with a reported Kd of approximately 5 μM for binding at the Vps29–Vps35 interface. It reduces Aβ peptide accumulation and modulates the APP-processing pathway in reported Alzheimer’s disease-related models.
Retromer dysfunction affects endosomal trafficking, APP processing and neurodegenerative disease pathways. R55 is useful for studying retromer stabilization, endosomal sorting and Aβ-generating mechanisms.
Key Features
- Retromer pharmacological chaperone
- Binds the Vps29–Vps35 interface
- Kd: approximately 5 μM
- Reduces Aβ peptide accumulation in reported assays
Applications
- Retromer biology research
- APP-processing pathway studies
- Alzheimer’s disease model assays
- Endosomal trafficking and sorting studies
More Information
| Parent CAS No. | 769856-81-7 |
|---|---|
| Chemical Name | thiophene-2,5-diylbis(methylene) dicarbamimidothioate dihydrochloride |
| SMILES | C1=C(CSC(=N)N)SC(CSC(=N)N)=C1.Cl.Cl |
| MFCD | N.A. |
| InChi | InChI=1S/C8H12N4S3.2ClH/c9-7(10)13-3-5-1-2-6(15-5)4-14-8(11)12;;/h1-2H,3-4H2,(H3,9,10)(H3,11,12);2*1H |
| InChiKey | DSODRWWHAUGSGD-UHFFFAOYSA-N |
| CID | 14040781 |
| Short Description | Retromer chaperone |
References
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