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(S)-3,5-DHPG
- (S)-3,5-Dihydroxyphenylglycine
- Optical Purity: >99%
- Soluble in water and DMSO
- MF: C8H9NO4
- MW: 183.16
Description
(S)-3,5-DHPG is the active enantiomer of DHPG and a potent, selective group I metabotropic glutamate receptor agonist for mGluR1 and mGluR5.
Activation of mGluR1/5 modulates neuronal excitability, synaptic plasticity and intracellular calcium signaling. (S)-3,5-DHPG is widely used to trigger group I mGlu receptor responses in neuroscience models.
Key Features
- Active S-enantiomer of 3,5-DHPG
- Potent agonist of mGluR1 and mGluR5
- Activates group I metabotropic glutamate receptor signaling
- Useful benchmark for glutamatergic GPCR studies
Applications
- mGluR1/mGluR5 activation assays
- Synaptic plasticity research
- Neuronal injury and excitability models
- Glutamate receptor pharmacology
Note: (S)-3,5-DHPG is the active enantiomer of racemic 3,5-DHPG (Axon 1739).
More Information
| Parent CAS No. | 162870-29-3 |
|---|---|
| Chemical Name | (S)-2-amino-2-(3,5-dihydroxyphenyl)acetic acid |
| SMILES | C1(O)C=C(O)C=C([C@@H](C(=O)O)N)C=1 |&1:7,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C8H9NO4/c9-7(8(12)13)4-1-5(10)3-6(11)2-4/h1-3,7,10-11H,9H2,(H,12,13)/t7-/m0/s1 |
| InChiKey | HOOWCUZPEFNHDT-ZETCQYMHSA-N |
| CID | 443586 |
| Short Description | mGluR1 agonist |
References
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