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AZ 12216052
- Soluble in DMSO
- MF: C19H22BrNOS
- MW: 392.35
Description
AZ 12216052 is a positive allosteric modulator (PAM) of metabotropic glutamate receptor subtype 8 (mGluR8).
mGluR8 is a presynaptic group III metabotropic glutamate receptor involved in regulation of neurotransmitter release. AZ 12216052 is useful for studying allosteric enhancement of mGluR8 signaling and glutamatergic circuit modulation.
Key Features
- Positive allosteric modulator of mGluR8
- Enhances group III mGlu receptor signaling
- Targets presynaptic glutamate receptor pharmacology
- Useful tool for allosteric GPCR modulation
Applications
- mGluR8 receptor pharmacology
- Glutamate release and synaptic signaling studies
- Allosteric modulator assay development
- CNS circuit and behavioral pharmacology
More Information
| Parent CAS No. | 1290628-31-7 |
|---|---|
| Chemical Name | 2-(4-bromobenzylthio)-N-(4-sec-butylphenyl)acetamide |
| SMILES | C1C=C(NC(=O)CSCC2C=CC(Br)=CC=2)C=CC=1C(CC)C |
| MFCD | N.A. |
| InChi | InChI=1S/C19H22BrNOS/c1-3-14(2)16-6-10-18(11-7-16)21-19(22)13-23-12-15-4-8-17(20)9-5-15/h4-11,14H,3,12-13H2,1-2H3,(H,21,22) |
| InChiKey | QKUYZJOTWYRWNF-UHFFFAOYSA-N |
| CID | 73755190 |
| Short Description | mGluR8 PAM |
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