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GYKI 53655
- LY 300168
- Soluble in DMSO and EtOH
- MF: C19H20N4O3
- MW: 352.39
Description
GYKI 53655 (LY300168) is a selective, non-competitive AMPA-type glutamate receptor antagonist that blocks AMPA receptor-mediated excitatory neurotransmission.
GYKI 53655 binds outside the glutamate recognition site and can distinguish AMPA receptor responses from kainate and NMDA receptor signaling. Its non-competitive mechanism and in vivo utility make it a valuable tool for seizure, synaptic transmission and excitotoxicity research.
Key Features
- Selective non-competitive AMPA receptor antagonist
- Blocks AMPA-mediated fast excitatory transmission
- Does not compete at the glutamate binding site
- Suitable for in vitro and in vivo glutamatergic studies
Applications
- AMPA receptor electrophysiology
- Excitatory synaptic transmission research
- Seizure and anticonvulsant models
- Excitotoxicity and neuroprotection studies
More Information
| Parent CAS No. | 143692-18-6 |
|---|---|
| Chemical Name | 5-(4-Amino-phenyl)-8-methyl-8,9-dihydro-1,3-dioxa-6,7-diaza-cyclohepta[f]indene-7-carboxylic acid methylamide |
| SMILES | C12OCOC=1C=C1C(C3C=CC(N)=CC=3)=NN(C(=O)NC)C(C)CC1=C2 |
| MFCD | MFCD00915789 |
| InChi | InChI=1S/C19H20N4O3/c1-11-7-13-8-16-17(26-10-25-16)9-15(13)18(22-23(11)19(24)21-2)12-3-5-14(20)6-4-12/h3-6,8-9,11H,7,10,20H2,1-2H3,(H,21,24) |
| InChiKey | SMGACXZFVXKEAX-UHFFFAOYSA-N |
| CID | 126758 |
| Short Description | AMPA antagonist |
References
- BA Chizh et al. A comparison of intravenous NBQX and GYKI 53655 as AMPA antagonists in the rat spinal cord. Br. J. Pharmacol. 1994, 112(3), 843-6.
- AD Kovács and G Szabó. GYKI 53655, a 2,3-benzodiazepine, non-competitively protects cultured neurones against AMPA toxicity. Eur. J. Pharmacol. 1997, 331(1), 93-96.
- Szabados et al. Comparison of anticonvulsive and acute neuroprotective activity of three 2,3-benzodiazepine compounds, GYKI 52466, GYKI 53405 and GYKI 53655. Brain. Res. Bull. 2001, 55 387.
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