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RO 25-6981 hydrochloride
- Parent CAS: 169274-78-6
- Optical Purity: 99.5% d.e.
- Soluble in water and DMSO
- MF: C22H29NO2.HCl
- MW: 375.93
Description
RO 25-6981 hydrochloride is a potent and selective NR2B/GluN2B-containing NMDA receptor antagonist with an IC50 value of 9 nM, compared to 52 μM at GluN1/GluN2A receptors.
NR2B-containing NMDA receptors are implicated in excitotoxicity, neuropathic pain, synaptic plasticity and neurodegeneration-related pathways. RO 25-6981 is used to selectively block GluN2B-mediated NMDA receptor signaling.
Key Features
- Selective GluN2B/NR2B NMDA receptor antagonist
- Blocks subtype-specific glutamatergic signaling
- Useful for excitotoxicity and pain pathway studies
- Reference compound for NR2B receptor pharmacology
Applications
- NMDA NR2B receptor assays
- Glutamate receptor subtype profiling
- Neuropathic pain and excitotoxicity models
- Synaptic plasticity and CNS pathway research
RO 25-6981 hydrochloride is an optimal water soluble salt form. Its other water-soluble salt form, RO 25-6981 maleate (Axon 2601) is also available for comparative formulation needs.
More Information
| Parent CAS No. | 169274-78-6 |
|---|---|
| Chemical Name | 4-[(1R,2S)-3-(4-Benzyl-piperidin-1-yl)-1-hydroxy-2-methyl-propyl]-phenol hydrochloride |
| SMILES | C1(O)C=CC([C@@H]([C@H](CN2CCC(CC3C=CC=CC=3)CC2)C)O)=CC=1.Cl |&1:5,6,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C22H29NO2.ClH/c1-17(22(25)20-7-9-21(24)10-8-20)16-23-13-11-19(12-14-23)15-18-5-3-2-4-6-18;/h2-10,17,19,22,24-25H,11-16H2,1H3;1H/t17-,22+;/m0./s1 |
| InChiKey | MKTZWXWTQQOMSH-OTCZLQCGSA-N |
| CID | 11957690 |
| Short Description | NR2B antagonist |
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