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Lamotrigine
- Soluble in DMSO
- MF: C9H7Cl2N5
- MW: 256.09
Description
Lamotrigine is an anticonvulsant that preferentially stabilizes the inactivated state of voltage-gated sodium channels, thereby limiting repetitive neuronal firing and reducing release of excitatory neurotransmitters including glutamate.
Lamotrigine is widely used as a reference compound for sodium-channel-dependent excitability, synaptic glutamate release and seizure pharmacology. Its mechanism is distinct from direct glutamate receptor antagonism.
Key Features
- Use-dependent voltage-gated sodium channel inhibitor
- Reduces repetitive neuronal firing
- Decreases presynaptic release of glutamate and aspartate
- Clinically established anticonvulsant and mood-stabilizing pharmacology
Applications
- Voltage-gated sodium channel studies
- Seizure and neuronal excitability models
- Presynaptic glutamate release assays
- Anticonvulsant and mood-disorder research
More Information
| Parent CAS No. | 84057-84-1 |
|---|---|
| Chemical Name | 6-(2,3-Dichloro-phenyl)-[1,2,4]tria zine-3,5-diamine |
| SMILES | C1(N=NC(N)=NC=1N)C1=CC=CC(Cl)=C1Cl |
| MFCD | MFCD00865333 |
| InChi | InChI=1S/C9H7Cl2N5/c10-5-3-1-2-4(6(5)11)7-8(12)14-9(13)16-15-7/h1-3H,(H4,12,13,14,16) |
| InChiKey | PYZRQGJRPPTADH-UHFFFAOYSA-N |
| CID | 3878 |
| Short Description | Glutamate antagonist |
References
- L Barbosa et al. A double-blind, randomized, placebo-controlled trial of augmentation with lamotrigine or placebo in patients concomitantly treated with fluoxetine for resistant major depressive episodes. J. Clin. Psychiatry. 2003, 6(4), 403–407.
- WJ Curry and DL Kulling. Newer Antiepileptic Drugs: Gabapentin, Lamotrigine, Felbamate, Topiramate and Fosphenytoin. Am. Fam. Physician. 1998, 57(3), 513.
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