Bulk Inquiry
CPPHA
- Soluble in DMSO
- MF: C22H15ClN2O4
- MW: 406.82
Description
CPPHA is a metabotropic glutamate receptor 5 (mGluR5) positive allosteric modulator (PAM) that potentiates glutamate signaling through an allosteric site distinct from the classical MPEP site.
CPPHA is useful for investigating allosteric-site diversity, receptor cooperativity and stimulus-dependent mGlu5 signaling. Its pharmacology supports mechanistic studies of synaptic plasticity and glutamate-receptor modulation.
Key Features
- mGluR5 positive allosteric modulator
- Binds a non-MPEP allosteric site
- Enhances glutamate-dependent receptor responses
- Useful for probing allosteric-site diversity
Applications
- mGluR5 functional and calcium-signaling assays
- Allosteric cooperativity studies
- Synaptic plasticity research
- Glutamate receptor modulator profiling
More Information
| Parent CAS No. | 693288-97-0 |
|---|---|
| Chemical Name | N-(4-Chloro-2-((1,3-dioxoisoindolin-2-yl)methyl)phenyl)-2-hydroxybenzamide |
| SMILES | C12C(=O)N(CC3=C(NC(=O)C4=CC=CC=C4O)C=CC(Cl)=C3)C(=O)C=1C=CC=C2 |
| MFCD | MFCD12912405 |
| InChi | InChI=1S/C22H15ClN2O4/c23-14-9-10-18(24-20(27)17-7-3-4-8-19(17)26)13(11-14)12-25-21(28)15-5-1-2-6-16(15)22(25)29/h1-11,26H,12H2,(H,24,27) |
| InChiKey | UFOUABRZSDGGAZ-UHFFFAOYSA-N |
| CID | 9931205 |
| Short Description | mGluR5 PAM |
References
- J O'Brien et al. A novel selective allosteric modulator potentiates the activity of native metabotropic glutamate receptor subtype 5 in rat forebrain. J. Pharmacol. Exp. Ther. 2004, 309, 568-577.
- Y Chen et al. N-{4-Chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide (CPPHA) Acts through a Novel Site as a Positive Allosteric Modulator of Group 1 Metabotropic Glutamate Receptors. Mol. Pharmacol. 2008, 73, 909-918.
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