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Gavestinel
- GV 150526A
- Parent CAS: 153436-22-7
- Soluble in DMSO
- MF: C18H11Cl2N2NaO3
- MW: 397.19
Description
Gavestinel is an in vivo active and orally bioavailable NMDA receptor glycine-site antagonist that blocks the co-agonist site required for NMDA receptor activation.
The glycine modulatory site is essential for NMDA receptor channel opening and excitatory neurotransmission. Gavestinel has been used to investigate neuroprotection and excitotoxicity in ischemic stroke-related animal models.
Key Features
- Selective antagonist of the NMDA receptor glycine site
- Blocks co-agonist-dependent NMDA receptor activation
- In vivo active pharmacology profile
- Relevant to excitotoxicity and neuroprotection research
Applications
- NMDA receptor glycine-site assays
- Excitotoxicity model research
- Ischemic stroke pharmacology studies
- Glutamate receptor antagonist profiling
More Information
| Parent CAS No. | 153436-22-7 |
|---|---|
| Chemical Name | 4,6-Dichloro-3-((E)-2-phenylcarbamoyl-vinyl)-1H-indole-2-carboxylic acid sodium salt |
| SMILES | C1(NC(=O)/C=C/C2=C(C([O-])=O)NC3C=C(Cl)C=C(Cl)C=32)C=CC=CC=1.[Na+] |
| MFCD | MFCD03700712 |
| InChi | InChI=1S/C18H12Cl2N2O3.Na/c19-10-8-13(20)16-12(17(18(24)25)22-14(16)9-10)6-7-15(23)21-11-4-2-1-3-5-11;/h1-9,22H,(H,21,23)(H,24,25);/q;+1/p-1/b7-6+; |
| InChiKey | GRSDSTMFQHAESM-UHDJGPCESA-M |
| CID | 16759177 |
| Short Description | Glycine antagonist |
References
- Mugnaini et al. Receptor binding characteristics of the novel NMDA receptor glycine site antagonist [3H]GV150526A in rat cerebral cortical membranes. Eur. J. Pharmacol. 2002, 391, 233.
- Kajbaf et al. Pharmacokinetics, metabolism and excretion of the glycine antagonist GV150526A in rat and dog. Xenobiotica. 2003, 33, 415.
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