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S 18986
- Optical Purity: >99% e.e.
- Soluble in DMSO
- MF: C10H12N2O2S
- MW: 224.28
Description
More Information
| Parent CAS No. | 175340-20-2 |
|---|---|
| Chemical Name | (+)-(S)-2,3,3a,4-Tetrahydro-1H-pyrrolo[2,1-c][1,2,4]benzothiadiazine-5,5-dioxide |
| SMILES | S1(=O)(=O)C2=CC=CC=C2N2CCC[C@]2([H])N1 |&1:13,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C10H12N2O2S/c13-15(14)9-5-2-1-4-8(9)12-7-3-6-10(12)11-15/h1-2,4-5,10-11H,3,6-7H2/t10-/m1/s1 |
| InChiKey | MNTIJYGEITVWHU-SNVBAGLBSA-N |
| CID | 637863 |
| Short Description | AMPA PAM |
References
- B Lockhart et al. (S)-2,3-dihydro-[3,4]cyclopentano-1,2,4-benzothiadiazine-1,1-dioxide: (S18986-1) a positive modulator of AMPA receptors enhances (S)-AMPA-mediated [3H]noradrenaline release (...). Eur. J. Pharmacol. 2000, 401(2), 145–153.
- C Lebrun et al. Effects of S 18986-1, a novel cognitive enhancer, on memory performances in an object recognition task in rats. Eur. J. Pharmacol. 2000, 401(2), 205–212.
- SM Gupta et al. GAP-43 is essential for the neurotrophic effects of BDNF and positive AMPA receptor modulator S18986. Cell Death Differ. 2009, 16(4), 624–637.
- KD Destot-Wong et al. The AMPA receptor positive allosteric modulator, S18986, is neuroprotective against neonatal excitotoxic and inflammatory brain damage through BDNF synthesis. Neuropharmacology 2009, 57(3), 277–286.
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