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Prucalopride
Axon 1479
CAS:
179474-81-8
Purity:
99%
- Soluble in DMSO
- MF: C18H26ClN3O3
- MW: 367.87
Description
Selective 5-HT4 receptor agonist; a gastroprokinetic agent for the treatment of constipation and irritable bowel syndrome; showed memory-enhancing effects in mice through modulation of cholinergic pathways; hence an indication of potential as Alzheimer's disease therapy
More Information
| Parent CAS No. | 179474-81-8 |
|---|---|
| Chemical Name | 4-Amino-5+K445-chloro-2,3-dihydro-benzofuran-7-carboxylic acid [1-(3-methoxy-propyl)-piperidin-4-yl]-amide |
| SMILES | C1(Cl)C=C(C(=O)NC2CCN(CCCOC)CC2)C2OCCC=2C=1N |
| MFCD | MFCD09837787 |
| InChi | InChI=1S/C18H26ClN3O3/c1-24-9-2-6-22-7-3-12(4-8-22)21-18(23)14-11-15(19)16(20)13-5-10-25-17(13)14/h11-12H,2-10,20H2,1H3,(H,21,23) |
| InChiKey | ZPMNHBXQOOVQJL-UHFFFAOYSA-N |
| CID | 3052762 |
| Short Description | 5-HT4 agonist |
References
- EP Bouras et al. Selective stimulation of colonic transit by the benzofuran 5HT4 agonist, prucalopride, in healthy humans. Gut. 1999, 44(5), 682-6.
- JH De Maeyer et al. 5-HT4 receptor agonists: similar but not the same. Neurogastroenterol. Motility. 2008, 20(2), 99-112.
- J Tack et al. Prucalopride (resolor(R)) in the treatment of severe chronic constipation in patients dissatisfied with laxatives. Gut. 2009, 58(3), 357-65.
- M Cachard-Chastel et al. Prucalopride and donepezil act synergistically to reverse scopolamine-induced memory deficit in C57Bl/6j mice. Behav. Brain Res. 2008, 187(2), 455-61.
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