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Usmarapride
- SUVN D4010
Axon 3595
- Parent CAS: 1428862-32-1
Purity:
99%
- Soluble in water, 0.1N HCl(aq) and DMSO
- MF: C21H29N5O2.C2H2O4
- MW: 473.52
Description
Usmarapride is a potent, selective and orally bioavailable 5-HT4 receptor partial agonist with an EC50 value of 44 nM. Usmarapride showed high selectivity against ganglionic 5-HT3 receptor and other closely related receptors and good pharmacokinetics in rats, dogs, and healthy humans. It also showed promising in vivo efficacy in animal models of cognition. Additionally, Usmarapride increased neuroprotective sAPPα levels and may possess disease-modifying potential.
More Information
| Parent CAS No. | 1428862-32-1 |
|---|---|
| Chemical Name | 2-(1-Isopropyl-1H-indazol-3-yl)-5-(1-(3-methoxypropyl)piperidin-4-yl)-1,3,4-oxadiazole oxalate |
| SMILES | C1C=C2C(C3=NN=C(C4CCN(CCCOC)CC4)O3)=NN(C(C)C)C2=CC=1.OC(C(=O)O)=O |
| MFCD | N.A. |
| InChi | InChI=1S/C21H29N5O2.C2H2O4/c1-15(2)26-18-8-5-4-7-17(18)19(24-26)21-23-22-20(28-21)16-9-12-25(13-10-16)11-6-14-27-3;3-1(4)2(5)6/h4-5,7-8,15-16H,6,9-14H2,1-3H3;(H,3,4)(H,5,6) |
| InChiKey | XHXCJKNEBFAUSE-UHFFFAOYSA-N |
| CID | 71508290 |
| Short Description | 5-HT4 receptor partial agonist |
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