ERES

ERES

FLI 06 (Axon 2277) is an inhibitor of endoplasmic reticulum (ER) export. This compound has the unique property to inhibit cargo recruitment to ER exit sites (ERESs): it disrupts the Golgi apparatus in a manner distinct from that of brefeldin A and golgicide A. FLI-06 inhibits general secretion at a step before exit from the endoplasmic reticulum (ER), which is accompanied by a tubule-to-sheet morphological transition of the ER, rendering it the first small molecule acting at such an early stage in secretory traffic. As such, it effectuates the accumulation of NotchΔE-eGFP in intracellular membranes.

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    FLI 06
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More About ERES

FLI 06 (Axon 2277) is an inhibitor of endoplasmic reticulum (ER) export. This compound has the unique property to inhibit cargo recruitment to ER exit sites (ERESs): it disrupts the Golgi apparatus in a manner distinct from that of brefeldin A and golgicide A. FLI-06 inhibits general secretion at a step before exit from the endoplasmic reticulum (ER), which is accompanied by a tubule-to-sheet morphological transition of the ER, rendering it the first small molecule acting at such an early stage in secretory traffic. As such, it effectuates the accumulation of NotchΔE-eGFP in intracellular membranes[1].

[1] A. Krämer et al. Small molecules intercept Notch signaling and the early secretory pathway. Nat. Chem. Biol. 2013, 9, 731-738.

 

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