URAT

Uric acid is the end product of purine metabolism in humans. Its synthesis is catalyzed by xanthine oxidoreductase and is mainly produced in liver, muscles, and intestine. Uric acid transporter URAT1, a 12-transmembrane domain-containing protein found in the apical membrane of proximal tubule epithelial cells and transports urate in exchange for Cl- or organic anions[1], contributes significantly to reabsorption of uric acid in humans to maintain a constant serum uric acid (SUA) level. Alterations of SUA level are linked to various human diseases, such as hypertension, cardiovascular disease, kidney disease, multiple sclerosis, Parkinson's disease, Alzheimer's disease, and optic neuritis[2]. Gout is yet another example of a commonly occurring disease that is triggered by the crystallization of uric acid within the joints; a type of inflammatory arthritis and is often associated with hyperuricemia[3].


[1] A So et al. Uric acid transport and disease. J Clin Invest. 2010 Jun 1; 120(6): 1791–1799.
[2] M Sato et al. Identification and functional characterization of uric acid transporter Urat1 (Slc22a12) in rats. Biochim Biophys Acta. 2011 Jun;1808(6):1441-7.
[3] K Hyon et al. Pathogenesis of Gout. Ann Intern Med. 2005;143:499-516.

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2581 UR 1102 Selective inhibitor of the renal urate transporter URAT1 €105.00

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