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Radafaxine hydrochloride
- (2S,3S)-Hydroxybupropion hydrochloride - GW 353162A
Axon 1123
- Parent CAS: 192374-14-4
- Optical Purity: Optically pure
- Soluble in water
- MF: C13H18ClNO2.HCl
- MW: 292.2
Description
Radafaxine hydrochloride (aka (2S,3S)-Hydroxybupropion hydrochloride - GW 353162A) is a norepinephrine-dopamine reuptake inhibitor (NDRI) and a potent metabolite of bupropion (Axon 1451). It is the (+)-isomer of hydroxybupropion and is useful for monoamine transporter research.
NDRI compounds increase extracellular norepinephrine and dopamine by inhibiting transporter-mediated reuptake. Radafaxine hydrochloride supports studies of bupropion metabolite pharmacology, catecholamine signaling and antidepressant-related mechanisms.
Key Features
- Norepinephrine-dopamine reuptake inhibitor
- Potent bupropion metabolite
- (+)-isomer of hydroxybupropion
- Supports mechanism-focused pharmacology and assay development
Applications
- DAT and NET transporter research
- Monoamine reuptake inhibition studies
- Bupropion metabolite profiling
- Antidepressant mechanism research
More Information
| Parent CAS No. | 192374-14-4 |
|---|---|
| Chemical Name | (2S,3S)-2-(3-Chloro-phenyl)-3,5,5-trimethyl-morpholin-2-ol hydrochloride |
| SMILES | [C@@]1(O)(C2C=C(Cl)C=CC=2)[C@H](C)NC(C)(C)CO1.Cl |&1:0,9,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C13H18ClNO2.ClH/c1-9-13(16,17-8-12(2,3)15-9)10-5-4-6-11(14)7-10;/h4-7,9,15-16H,8H2,1-3H3;1H/t9-,13+;/m0./s1 |
| InChiKey | ORXTVTDGPVINDN-BTJVGWIPSA-N |
| CID | 9838996 |
| Short Description | NDRI |
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