Bulk Inquiry
Bupropion hydrochloride
- BW 322U - BVF 033 - Amfebutamone
Axon 1451
- Parent CAS: 34911-55-2
Purity:
99%
- Soluble in water and DMSO
- MF: C13H18ClNO.HCl
- MW: 276.2
Description
Bupropion hydrochloride is a norepinephrine and dopamine reuptake inhibitor that also acts as a non-competitive antagonist at several neuronal nicotinic acetylcholine receptors.
Bupropion increases catecholaminergic neurotransmission by inhibiting NET and DAT and reduces nicotinic receptor signaling associated with nicotine reinforcement. It is a clinically established reference for antidepressant and smoking-cessation pharmacology.
Key Features
- Norepinephrine–dopamine reuptake inhibitor
- Non-competitive neuronal nicotinic receptor antagonist
- Enhances catecholaminergic neurotransmission
- Clinically validated antidepressant and smoking-cessation pharmacology
Applications
- DAT and NET uptake assays
- Nicotinic acetylcholine receptor studies
- Depression and monoamine-signaling models
- Nicotine dependence and reward-pathway research
More Information
| Parent CAS No. | 34911-55-2 |
|---|---|
| Chemical Name | 1-(3-Chlorophenyl)-2-[(1,1-dimethylethyl)amino]-1-propanone hydrochloride |
| SMILES | C1(Cl)C=C(C(=O)C(NC(C)(C)C)C)C=CC=1.Cl |
| MFCD | MFCD00055209 |
| InChi | InChI=1S/C13H18ClNO.ClH/c1-9(15-13(2,3)4)12(16)10-6-5-7-11(14)8-10;/h5-9,15H,1-4H3;1H |
| InChiKey | HEYVINCGKDONRU-UHFFFAOYSA-N |
| CID | 62884 |
| Short Description | NDRI |
Bupropion hydrochloride
norepinephrine–dopamine reuptake inhibitor
NDRI
BW 322U
BVF 033
Amfebutamone
BW322U
BVF033
SLC6A3
SLC6A2
norepinephrine–dopamine reuptake
Inhibitor
dopamine signaling
cholinergic signaling
DAT and NET uptake assays
Nicotinic acetylcholine receptor studies
Depression and monoamine-signaling models
Nicotine dependence and reward-pathway research
neuroscience
addiction research
depression research
GPCR pharmacology
transporter pharmacology
signal transduction
CAS 34911-55-2
CAS 31677-93-7
Axon Medchem
Axon 1451
Supplier
Vendor
References
- RA Sweet et al. Pharmacokinetics of single-and multiple dose bupropion in elderly patients with depression. J Clin Pharmacol 1995, 35(9), 876-884.
- RT Segraves et al. Evaluation of sexual functioning depressed outpatients: A double-blind comparison of sustained-release bupropion and sertraline treatment. J Clin Psychopharmacol 2000, 20(2), 122-128.
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 1123 | Radafaxine hydrochloride |
From $132.00 |
| 1203 | GBR 12783 dihydrochloride |
From $99.00 |
| 3355 | IDT307 |
From $99.00 |
Other Categories
Get a Quote for
Loading...