Inositol lipids have specialized functions in eukaryotic organisms. Not only do they provide a source of second messengers but they are also recognized as signaling molecules. Moreover, inositol lipids are required as substrates for PLC and PI3K activities, as well as having a role in cytoskeletal reorganization and vesicular traffic. The cytosolic protein Phosphatidylinositoltransfer protein (PITP) is a key regulator of the cellular mechanism that can compartmentalize the synthesis of these phosphoinositides[1]. PIPTs mediate the transfer of monomeric phosphatidylinositol (PI) or phosphatidylcholine (PC) molecules between two membrane compartments of a cell.